Surprise package of the season, Watford will host under pressure Manchester United at the Vicarage Road. The host are third on the table behind Chelsea and Liverpool and have won all their four prvious matches this season. While Manchester United are 10th on the log with only six points after winning twice and losing same number of matches.
The Hornets did beat United 3-1 at home in the Premier League in September 2016. But, Manchester United won this fixture 4-2 last season, with former Hornet Ashley Young scoring twice.
Earlier today Hotspur will host Liverpool in the star match of the weekend.
Chelsea welcome Cardiff City at the Stamford Bridge while fourth placed Manchester City will host Fulham. Arsenal will visit Newcastle United, who are yet to get their first win of the season.