Manchester City leapfrogged Chelsea into the top four with a 3-1 victory over the Blues at Stamford Bridge.
Noni Madueke gave Chelsea a third minute lead, but the home side failed to consolidate on their lead until Josko Gvardiol equalized three minutes to the break.
After the break, Erling Haaland scored his 18th league goal of the season as he capitalized on the error of Chelsea goalkeeper Sanchez to chip the ball into the net.
Chelsea, who had lost their opening day match of this season to Manchester City could not find the equalizer, rather Phil Foden put the icing on the cake with City’s third goal.
With this defeat, Chelsea are without a win in 11 meetings with Manchester City.
In other matches, Bournemouth derived enough vitality from the Vitality Stadium to spank third-placed Nottingham Forest 5-0 as Everton shocked Brighton 1-0 at the American Express Stadium.
League leaders Liverpool sustained the momentum with a 4-1 victory over Ipswich Town as bottom placed Southampton were beaten 3-1 by visiting Newcastle United.
Arsenal maintained their second place after a laborious 1-0 victory over Wolverhampton Wanderers.
Action will continue on Sunday when Crystal Palace host Brentford as Tottenham Hotspurs host Leicester City.
Aston Villa will welcome West Ham to the Villa Park as Fulham lurk horns with Manchester United.
